Bipolar disorder affects millions of Americans, and is
a difficult condition to diagnose using conventional methodology. Psynomics
Inc. offers the first and only DNA-based test to help diagnose and treat
Historically, diagnosis of psychiatric illness has centered on subjective evaluation
of the patient’s reported behaviors and feelings. No objective
bases for evaluation has been available. As such, accurate diagnosis
has been extremely challenging, particularly in illnesses such as this
with many variations that may appear to be a different illness altogether.
Psynomics’ scientists discovered the first gene
linked to bipolar disorder and developed Psynome™, the
genetic test for bipolar disorder. Psynome™ can help your
doctor to more quickly and accurately determine an appropriate diagnosis
for you, and if you are bipolar, help predict which drug therapies might
Psynomics’ DNA-based test is the only objective
test available for bipolar disorder.
for gene mutations in the Promoter L allele gene that predicts a patient’s
likely response to serotonin-based drugs, the most commonly prescribed
drug therapies in psychiatry today.
for an individual’s favorable or unfavorable response to serotonin-based
drugs can provide your doctor with a tool to significantly reduce the “guess-work” involved
in traditional“trial and error” protocols.
In total confidentiality, the test will include
- DNA sample collection: A package will be
mailed to you containing a "spit kit". To collect cells containing your DNA,
you deposit your saliva into the kit’s marked and re-sealable
container. The collection procedure is safe, painless and takes
only three minutes. A small sample of your saliva contains enough
DNA for our tests. You will mail your sample back to Psynomics
in a return-postage paid envelope. Only a code number will be
used to identify you on the mailer, assuring complete confidentiality.
- DNA testing: Your DNA will be tested for GRK3 and two of its
genetic variations. Your DNA will also be tested for response
to serotonin-based drugs, the basic element used in most types
of drug therapy used today.
- Psynomics scientists will evaluate
your test results and provide a report summarizing them along
with an explanation of what this means directly to your health
care provider (“doctor”). If you order both
tests, your doctor will receive a combined report for the two tests. Psynomics’ report
to your doctor will indicate the appropriate diagnosis for you as well
as the appropriate drug therapy to help you feel better.
You Should Consider Testing If:
- You have had problems with depression, mania or irritability and
want to know if you have a genetic predisposition to bipolar disorder
and whether you should seek treatment.
- You are currently being treated for depression or bipolar disorder
and you and your doctor want state-of-the-art DNA testing to help confirm
your diagnosis and choose the best treatment.
- You are being treated for depression and your doctor would like to
test you for possible bipolar disorder
- You and your doctor would like to know how you will likely respond
to serotonin-based drug treatments.
- You are being treated, but want a second opinion regarding your diagnosis
- You are being treated with, or are considering treatment
- You would like to learn more about the possible
role of genes for mood disorder in your illness and in your family.
What Can Testing Tell Me?
- Do I have a gene for bipolar disorder? There are likely dozens of
genes for bipolar disorder that combine to cause a risk for illness.
Psynomics will test you for one of the known genes, called GRK3, which
has been shown to be associated with bipolar disorder. If you have
this gene, then you are more likely to have bipolar disorder. GRK3
has several variations, and depending on which variation you have,
you will be two to three times more likely to have bipolar disorder
than someone without the gene.
- What treatments will help me? Your DNA
will be tested for genes that influence your response to the most
often prescribed drug therapies (serotonin-based) for depression and bipolar
disorder. Your history and diagnosis will also suggest likely treatments.
This information will be used by the Psynomics doctor to recommend
treatments likely to help. This information can then be used by your
doctor to select the best treatment.
What Can Psynomics Testing Not Tell Me?
- There is no definitive test for psychiatric diagnosis. Genes may
increase the probability that you have a given illness. A positive
test means you have a higher probability of having bipolar disorder.
You can have the GRK3 gene and not have bipolar disorder - but you
have a higher likelihood of doing so than another person without the
- A negative test is uninformative. Psynomics’ test
may rule out the role of some genes in your case, but you may still
have bipolar disorder as a result of other genetic causes or from
stress, environmental causes, illness or other factors.
- There is no definitive test to predict medication response. Psynomics
testing will indicate whether you have a higher or lower probability
of benefiting from SSRI (selective serotonin reuptake inhibitors) medications.
- It does not tell you if you will develop bipolar disorder in the
- It does not tell you if your children will develop a mood disorder.
How Will I Benefit?
- This test will lead to a more accurate diagnosis.
- This will in turn lead to the most appropriate treatment.
- You will better understand your diagnosis and your symptoms and their
impact on your life in the future.
- You can make more informed decisions with your doctor regarding your
- With appropriate diagnosis and treatment you will be more
stable and have more control over the impact of this illness on your